Detection of Minimal Residual Disease in Precursor B-Cell Neoplasms
Despite several developed treatment protocols used for treatment of patient with precursor B-cell leukemia/lymphoma, many of these patients relapse. Most of these patients relapse from clinically inapparent minimal residual disease (MRD), which refers to the presence of clonal cells in BM after treatment in a level below the morphological detection. The ability to predict who will relapse while still in a minimal disease state has important clinical implications. A reliable technique for MRD detection should be specific, sensitive, reproducible and quantitative. Currently, PCR analysis of Ag receptor gene rearrangements and flowcytometry represent the most clinically useful targets for MRD analysis in ALL. Molecular techniques may be sequence- or non sequence based methods. This book will discuss the basic knowledge about precursor B-cell neoplasms, MRD and different molecular methods for its detection with stress on a non-sequence based technique. This book should be useful for both medical student and medical professional in the field of laboratory or clinical hematology.
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The Canadian Real Estate Action Plan: Proven Investment Strategies to Kick Start and Build Your Portfolio
Peter Kinch???s Investors Succeed Because They Plan for Success Peter Kinch???s focus is on opening financing doors for real estate investors, and he is so successful at it that in 2008 he was named Canada???s Top Mortgage Broker. His track record and r
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Electrohydrodynamic stability: Effect of viscous irrotational stresses
The theory of hydrodynamic stability is useful in predicting transition between laminar and turbulent configuration for a given flow field i.e. hydrodynamic stability deals with predicting the most stable configuration for a given system and transition from laminar flow to turbulent flows as a natural progression of the system marked by the initial instability. One important problem in hydrodynamics is the impact of the electric field on the stability of two fluid systems. The discontinuity of the electric properties of the fluids across the interface affects the force balance at the fluid-fluid interface, which may either stabilize or destabilize the interface in question. There is increasing interest in the electrohydrodynamic stability as the electric field plays an important role in many practical problems of biophysics, chemical engineering and various other fields. In this book, the impact of electric field on the interfacial instability like Rayleigh-Taylor instability, Kelvin-Helmholtz instability has been presented. The effect of viscous irrotational stresses on the electrohydrodynamic stability has been formulated and solved.
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